Overexpression of Slit2 decreases neuronal excitotoxicity, accelerates glymphatic clearance, and improves cognition in a multiple microinfarcts model

Overexpression of Slit2 decreases neuronal excitotoxicity, accelerates glymphatic clearance, and improves cognition in a multiple microinfarcts model

Abstract Background Cerebral microinfarcts (MIs) lead to progressive cognitive impairments in the elderly, and there is currently no effective preventative strategy due to uncertainty about the underlying pathogenic mechanisms. One possibility is the dysfunction of GABAergic transmission and ensuing...

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Bibliographic Details
Main Authors: Xiao-fei He, Ge Li, Li-li Li, Ming-yue Li, Feng-yin Liang, Xi Chen, Xi-quan Hu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Molecular Brain
Subjects:
Slit2
Microinfarcts
Two-photon imaging
Cognition
Glymphatic clearance
Online Access:http://link.springer.com/article/10.1186/s13041-020-00659-5

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http://link.springer.com/article/10.1186/s13041-020-00659-5

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