A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids

A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids

The fatty acid desaturase (FADS) genes code for the rate-limiting enzymes required for the biosynthesis of long-chain polyunsaturated fatty acids (LCPUFA). Here we report discovery and function of a novel FADS1 splice variant. FADS1 alternative transcript 1 (FADS1AT1) enhances desaturation of FADS2,...

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Bibliographic Details
Main Authors: Woo Jung Park, Kumar S.D. Kothapalli, Holly T. Reardon, Peter Lawrence, Shu-Bing Qian, J. Thomas Brenna
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Journal of Lipid Research
Subjects:
alternative splicing
arachidonic acid
fatty acid desaturases
fatty acid biosynthesis
gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520418541

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http://www.sciencedirect.com/science/article/pii/S0022227520418541

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