Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells

Reactive oxygen species (ROS) are involved in various aspects of cancer cell biology, yet their role in cancer stem cells (CSCs) has been poorly understood. In particular, it still remains unclear whether and how ROS control the self-renewal/differentiation process and the tumor-initiating capacity...

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Bibliographic Details
Main Authors: Atsushi Sato, Masashi Okada, Keita Shibuya, Eriko Watanabe, Shizuka Seino, Yoshitaka Narita, Soichiro Shibui, Takamasa Kayama, Chifumi Kitanaka
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506113001384