Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells
Reactive oxygen species (ROS) are involved in various aspects of cancer cell biology, yet their role in cancer stem cells (CSCs) has been poorly understood. In particular, it still remains unclear whether and how ROS control the self-renewal/differentiation process and the tumor-initiating capacity...
Main Authors: | Atsushi Sato, Masashi Okada, Keita Shibuya, Eriko Watanabe, Shizuka Seino, Yoshitaka Narita, Soichiro Shibui, Takamasa Kayama, Chifumi Kitanaka |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2014-01-01
|
Series: | Stem Cell Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506113001384 |
Similar Items
-
Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners.
by: Tetsuhiro Chiba, et al.
Published: (2014-01-01) -
Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs
by: Tomomi Sanomachi, et al.
Published: (2019-10-01) -
Brexpiprazole, a Serotonin-Dopamine Activity Modulator, Can Sensitize Glioma Stem Cells to Osimertinib, a Third-Generation EGFR-TKI, via Survivin Reduction
by: Shuhei Suzuki, et al.
Published: (2019-07-01) -
Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing
by: Shuhei Suzuki, et al.
Published: (2020-08-01) -
Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction
by: Shuhei Suzuki, et al.
Published: (2021-08-01)