Insights into the Mechanism of Ethionamide Resistance in <i>Mycobacterium tuberculosis</i> through an <i>in silico</i> Structural Evaluation of EthA and Mutants Identified in Clinical Isolates

Insights into the Mechanism of Ethionamide Resistance in <i>Mycobacterium tuberculosis</i> through an <i>in silico</i> Structural Evaluation of EthA and Mutants Identified in Clinical Isolates

Mutation in the ethionamide (ETH) activating enzyme, EthA, is the main factor determining resistance to this drug, used to treat TB patients infected with MDR and XDR <i>Mycobacterium tuberculosis</i> isolates. Many mutations in EthA of ETH resistant (ETH-R) isolates have been described...

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Bibliographic Details
Main Authors: Vinicius Carius de Souza, Deborah Antunes, Lucianna H.S. Santos, Priscila Vanessa Zabala Capriles Goliatt, Ernesto Raul Caffarena, Ana Carolina Ramos Guimarães, Teca Calcagno Galvão
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Catalysts
Subjects:
EthA
ethionamide resistance
BVMO
molecular dynamics
thermodynamic integration
Online Access:https://www.mdpi.com/2073-4344/10/5/543

Internet

https://www.mdpi.com/2073-4344/10/5/543

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