Chitin induces steroid-resistant airway inflammation and airway hyperresponsiveness in mice

Chitin induces steroid-resistant airway inflammation and airway hyperresponsiveness in mice

Background: Previous reports have shown that pathogen-associated patterns (PAMPs) induce the production of interleukin (IL)-1β in macrophages. Moreover, studies using mouse models also suggest that chitin, which acts as a PAMP, induces adjuvant effects and eosinophilic infiltration in the lung. Thus...

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Bibliographic Details
Main Authors: Tomohito Takeshige, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Hitoshi Sasano, Yuuki Sandhu, Kei Matsuno, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Allergology International
Subjects:
Airway inflammation
Alveolar macrophages
Chitin
Interleukin-1β
Steroid-resistant asthma
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893021000083

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http://www.sciencedirect.com/science/article/pii/S1323893021000083

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