Diverse Action of Selected Statins on Skeletal Muscle Cells—An Attempt to Explain the Protective Effect of Geranylgeraniol (GGOH) in Statin-Associated Myopathy (SAM)

Diverse Action of Selected Statins on Skeletal Muscle Cells—An Attempt to Explain the Protective Effect of Geranylgeraniol (GGOH) in Statin-Associated Myopathy (SAM)

The present study is centered on molecular mechanisms of the cytoprotective effect of geranylgeraniol (GGOH) in skeletal muscle harmed by statin-associated myopathy (SAM). GGOH via autophagy induction was purportedly assumed to prevent skeletal muscle viability impaired by statins, atorvastatin (ATR...

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Bibliographic Details
Main Authors: Anna Jaśkiewicz, Beata Pająk, Magdalena Łabieniec-Watała, Clara De Palma, Arkadiusz Orzechowski
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Journal of Clinical Medicine
Subjects:
skeletal muscle cell viability
statins
myotoxicity
geranylgeraniol
water-soluble cholesterol
statin-associated myopathy
mitochondrial bioenergetics
Online Access:https://www.mdpi.com/2077-0383/8/5/694

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https://www.mdpi.com/2077-0383/8/5/694

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