The protective mechanism of SIRT1 on cartilage through regulation of LEF-1

Abstract Background Osteoarthritis (OA) is a chronic degenerative disease that suppresses middle-aged and older people worldwide. Silent information regulator 1(SIRT-1) is associated with several age-related diseases, such as cardiovascular diseases, neurodegenerative diseases and tumors, etc. The p...

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Bibliographic Details
Main Authors: Xueyu Hu, Gangning Feng, Zhiqiang Meng, Long Ma, Qunhua Jin
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Musculoskeletal Disorders
Subjects:
Online Access:https://doi.org/10.1186/s12891-021-04516-x