Chronic hypoxia induces the in vivo activation of the Wnt/β-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1deltaE9 transgenic mice

Chronic hypoxia induces the in vivo activation of the Wnt/β-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1deltaE9 transgenic mice

Hypoxia modulates proliferation and differentiation of cultured embryonic and adult stem cells, an effect that includes β-catenin a key component of the canonical Wnt signaling pathway. Here we studied in vivo the effect of mild hypoxia on the activity of the Wnt/β-catenin signaling pathway in the h...

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Bibliographic Details
Main Authors: Lorena eVarela-Nallar, Macarena eRojas-Abalos, Ana C. Abbott, Esteban A. Moya, Rodrigo eIturriaga, Nibaldo C. Inestrosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Hippocampus
Neurogenesis
Wnt Signaling Pathway
hypoxia
Alzheimer’s disease
HIF-1α
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00017/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00017/full

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