Increased Toxoplasma gondii Intracellular Proliferation in Human Extravillous Trophoblast Cells (HTR8/SVneo Line) Is Sequentially Triggered by MIF, ERK1/2, and COX-2

Increased Toxoplasma gondii Intracellular Proliferation in Human Extravillous Trophoblast Cells (HTR8/SVneo Line) Is Sequentially Triggered by MIF, ERK1/2, and COX-2

Macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine, which mediates the regulation of diverse cellular functions. It is produced by extravillous trophoblastic cells and has been found to be involved in the pathogenesis of diseases caused by some protozoa, including Tox...

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Bibliographic Details
Main Authors: Iliana Claudia Balga Milian, Rafaela José Silva, Camilla Manzan-Martins, Bellisa Freitas Barbosa, Pamela Mendonça Guirelli, Mayara Ribeiro, Angelica de Oliveira Gomes, Francesca Ietta, José Roberto Mineo, Priscila Silva Franco, Eloisa Amália Vieira Ferro
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Microbiology
Subjects:
Toxoplasma gondii
macrophage migration inhibitor factor (MIF)
CD44
ERK1/2 phosphorylation
COX-2
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00852/full

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00852/full

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