CD68+ Macrophage Infiltration Associates With Poor Outcome of HPV Negative Oral Squamous Carcinoma Patients Receiving Radiation: Poly(I:C) Enhances Radiosensitivity of CAL-27 Cells but Promotes Macrophage Recruitment Through HMGB1

CD68+ Macrophage Infiltration Associates With Poor Outcome of HPV Negative Oral Squamous Carcinoma Patients Receiving Radiation: Poly(I:C) Enhances Radiosensitivity of CAL-27 Cells but Promotes Macrophage Recruitment Through HMGB1

Patients with human papillomavirus (HPV) negative oral squamous cell carcinoma (OSCC) generally have poor clinical outcomes and worse responses to radiotherapy. It is urgent to explore the underlining mechanisms of the distinct prognoses between HPV negative and HPV positive OSCC and to develop effe...

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Bibliographic Details
Main Authors: Dan Ai, Yu Dou, Zhaodi Nan, Ketao Wang, Huayang Wang, Lin Zhang, Zuoqing Dong, Jintang Sun, Chao Ma, Wanye Tan, Wenjuan Gao, Jia Liu, Lei Zhao, Shaohua Liu, Bingfeng Song, Qianqian Shao, Xun Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
oral squamous cell carcinoma
human papillomavirus
radiosensitivity
poly(I:C)
HMGB1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.740622/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.740622/full

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