Enhanced Survival of Grafts Genetically Endowed with the Ability to Block CD2 and B7
In a model of transplantation rejection, we have tested whether a graft manipulated to secrete immunomodulators could protect itself from immune destruction. An insulinoma cell line having the NOD genotype but also expressing the neoantigen, SV40 T antigen, was transfected with CTLA4Ig or LFA3Ig to...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2001-03-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/000000001783986909 |