The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH

The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH

The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher cytoplasmic utilization of glucose (glycolysis), even in the presence of oxygen; this is known as the “Warburg Effect”. How...

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Bibliographic Details
Main Authors: Khalid O. Alfarouk, Samrein B. M. Ahmed, Robert L. Elliott, Amanda Benoit, Saad S. Alqahtani, Muntaser E. Ibrahim, Adil H. H. Bashir, Sari T. S. Alhoufie, Gamal O. Elhassan, Christian C. Wales, Laurent H. Schwartz, Heyam S. Ali, Ahmed Ahmed, Patrick F. Forde, Jesus Devesa, Rosa A. Cardone, Stefano Fais, Salvador Harguindey, Stephan J. Reshkin
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Metabolites
Subjects:
cancer
metabolism
enzyme
pH
redox
Online Access:https://www.mdpi.com/2218-1989/10/7/285

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https://www.mdpi.com/2218-1989/10/7/285

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