High-Throughput Detection of Autoantigen-Specific B Cells Among Distinct Functional Subsets in Autoimmune Donors

High-Throughput Detection of Autoantigen-Specific B Cells Among Distinct Functional Subsets in Autoimmune Donors

Antigen-specific B cells (ASBCs) can drive autoimmune disease by presenting autoantigen to cognate T cells to drive their activation, proliferation, and effector cell differentiation and/or by differentiating into autoantibody-secreting cells. Autoantibodies are frequently used to predict risk and d...

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Bibliographic Details
Main Authors: Bryan A. Joosse, James H. Jackson, Alberto Cisneros, Austin B. Santhin, Scott A. Smith, Daniel J. Moore, Leslie J. Crofford, Erin M. Wilfong, Rachel H. Bonami
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
B cells
B cell receptor (BCR)
autoimmune disease
autoantigen
myositis
Sjogren’s syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.685718/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.685718/full

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