The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates

The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates

Abstract Background Effective neurorestorative therapies of neurodegenerative diseases must be developed. There is increasing interest in using human platelet lysates, rich in neurotrophic factors, as novel disease-modifying strategy of neurodegeneration. To ensure virus safety, pathogen reduction t...

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Bibliographic Details
Main Authors: Ouada Nebie, David Devos, Valérie Vingtdeux, Lassina Barro, Jean-Christophe Devedjian, Aurélie Jonneaux, Ming-Li Chou, Régis Bordet, Luc Buée, Folke Knutson, David Blum, Thierry Burnouf
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Biomedical Science
Subjects:
Pathogen inactivation
Intercept-platelet lysate
Ferroptosis
Neuroprotection
LUHMES cells
Primary neurons
Online Access:http://link.springer.com/article/10.1186/s12929-019-0579-9

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http://link.springer.com/article/10.1186/s12929-019-0579-9

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