Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium/Diamine Co-Catalysis for One-Pot Hydration/Reduction Enantioselective Sequential Reaction of Alkynes
This study developed a cost-efficient hydration/asymmetric transfer hydrogenation (ATH) process for the one-pot synthesis of valuable chiral alcohols from alkynes. During this process, the initial homogeneous cobaloxime-catalyzed hydration of alkynes was followed by heterogeneous Ru/diamine-catalyze...
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Frontiers Media S.A.
2021-09-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.732542/full |
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doaj-97b5a86597654829bb8c873dc6588b642021-09-22T06:15:47ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-09-01910.3389/fchem.2021.732542732542Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium/Diamine Co-Catalysis for One-Pot Hydration/Reduction Enantioselective Sequential Reaction of AlkynesZeyang LiuYongjie WangKaihong LiuShanshan WangHaocheng LiaoYuanli ZhuBaoming HouChunxia TanGuohua LiuThis study developed a cost-efficient hydration/asymmetric transfer hydrogenation (ATH) process for the one-pot synthesis of valuable chiral alcohols from alkynes. During this process, the initial homogeneous cobaloxime-catalyzed hydration of alkynes was followed by heterogeneous Ru/diamine-catalyzed ATH transformation of the in-situ generated ketones, which provided varieties of chiral alcohols in good yields with up to 99% ee values. The immobilized Ru/diamine catalyst could be recycled at least three times before its deactivation in the sequential reaction system. This work shows a general method for developing one-pot asymmetric sequential catalysis towards sustainable organic synthesis.https://www.frontiersin.org/articles/10.3389/fchem.2021.732542/fullasymmetric catalysisheterogeneous catalystshydrationtransfer hydrogenationsilica |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zeyang Liu Yongjie Wang Kaihong Liu Shanshan Wang Haocheng Liao Yuanli Zhu Baoming Hou Chunxia Tan Guohua Liu |
spellingShingle |
Zeyang Liu Yongjie Wang Kaihong Liu Shanshan Wang Haocheng Liao Yuanli Zhu Baoming Hou Chunxia Tan Guohua Liu Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium/Diamine Co-Catalysis for One-Pot Hydration/Reduction Enantioselective Sequential Reaction of Alkynes Frontiers in Chemistry asymmetric catalysis heterogeneous catalysts hydration transfer hydrogenation silica |
author_facet |
Zeyang Liu Yongjie Wang Kaihong Liu Shanshan Wang Haocheng Liao Yuanli Zhu Baoming Hou Chunxia Tan Guohua Liu |
author_sort |
Zeyang Liu |
title |
Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium/Diamine Co-Catalysis for One-Pot Hydration/Reduction Enantioselective Sequential Reaction of Alkynes |
title_short |
Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium/Diamine Co-Catalysis for One-Pot Hydration/Reduction Enantioselective Sequential Reaction of Alkynes |
title_full |
Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium/Diamine Co-Catalysis for One-Pot Hydration/Reduction Enantioselective Sequential Reaction of Alkynes |
title_fullStr |
Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium/Diamine Co-Catalysis for One-Pot Hydration/Reduction Enantioselective Sequential Reaction of Alkynes |
title_full_unstemmed |
Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium/Diamine Co-Catalysis for One-Pot Hydration/Reduction Enantioselective Sequential Reaction of Alkynes |
title_sort |
integrated cobaloxime and mesoporous silica-supported ruthenium/diamine co-catalysis for one-pot hydration/reduction enantioselective sequential reaction of alkynes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Chemistry |
issn |
2296-2646 |
publishDate |
2021-09-01 |
description |
This study developed a cost-efficient hydration/asymmetric transfer hydrogenation (ATH) process for the one-pot synthesis of valuable chiral alcohols from alkynes. During this process, the initial homogeneous cobaloxime-catalyzed hydration of alkynes was followed by heterogeneous Ru/diamine-catalyzed ATH transformation of the in-situ generated ketones, which provided varieties of chiral alcohols in good yields with up to 99% ee values. The immobilized Ru/diamine catalyst could be recycled at least three times before its deactivation in the sequential reaction system. This work shows a general method for developing one-pot asymmetric sequential catalysis towards sustainable organic synthesis. |
topic |
asymmetric catalysis heterogeneous catalysts hydration transfer hydrogenation silica |
url |
https://www.frontiersin.org/articles/10.3389/fchem.2021.732542/full |
work_keys_str_mv |
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