Optimized sonoreactor for accelerative amyloid-fibril assays through enhancement of primary nucleation and fragmentation

Optimized sonoreactor for accelerative amyloid-fibril assays through enhancement of primary nucleation and fragmentation

Ultrasonication to supersaturated protein solutions forcibly forms amyloid fibrils, thereby allowing the early-stage diagnosis for amyloidoses. Previously, we constructed a high-throughput sonoreactor to investigate features of the amyloid-fibril nucleation. Although the instrument substantiated the...

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Bibliographic Details
Main Authors: Kichitaro Nakajima, Kentaro Noi, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Hirotsugu Ogi, Yuji Goto
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Ultrasonics Sonochemistry
Subjects:
Sonoreactor
Amyloid fibril
Nucleation
Fragmentation
Supersaturation
Sonocrystallization
Online Access:http://www.sciencedirect.com/science/article/pii/S135041772100050X

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http://www.sciencedirect.com/science/article/pii/S135041772100050X

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