Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration
Intravitreal administration of anti-vascular endothelial growth factor (VEGF) antibodies has become the standard treatment for Age-Related Macular Degeneration; however, the knowledge of their pharmacokinetics is limited. A comprehensive review of the preclinical and clinical pharmacokinetic data th...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-07-01
|
Series: | Pharmaceutics |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4923/11/8/365 |
id |
doaj-97ba863170094df488b83912357c7b69 |
---|---|
record_format |
Article |
spelling |
doaj-97ba863170094df488b83912357c7b692020-11-25T02:20:27ZengMDPI AGPharmaceutics1999-49232019-07-0111836510.3390/pharmaceutics11080365pharmaceutics11080365Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular DegenerationLaura García-Quintanilla0Andrea Luaces-Rodríguez1María Gil-Martínez2Cristina Mondelo-García3Olalla Maroñas4Víctor Mangas-Sanjuan5Miguel González-Barcia6Irene Zarra-Ferro7Pablo Aguiar8Francisco J. Otero-Espinar9Anxo Fernández-Ferreiro10Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainPharmacology Group, Health Research Institute of Santiago de Compostela (FIDIS), 15706 Santiago de Compostela, SpainOphthalmology Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainPharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainGenomic Medicine Group, Galician Public Foundation of Genomic Medicine, Health Research Institute of Santiago de Compostela (FIDIS), 15706 Santiago de Compostela, SpainDepartment of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, 46100 Valencia, SpainPharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainPharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainNuclear Medicine Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, SpainPharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainIntravitreal administration of anti-vascular endothelial growth factor (VEGF) antibodies has become the standard treatment for Age-Related Macular Degeneration; however, the knowledge of their pharmacokinetics is limited. A comprehensive review of the preclinical and clinical pharmacokinetic data that were obtained in different studies with intravitreal bevacizumab, ranibizumab, and aflibercept has been conducted. Moreover, the factors that can influence the vitreous pharmacokinetics of these drugs, as well as the methods that were used in the studies for analytical determination, have been exposed. These anti-VEGF drugs present different charge and molecular weights, which play an important role in vitreous distribution and elimination. The pharmacokinetic parameters that were collected differ depending on the species that were involved in the studies and on physiological and pathological conditions, such as vitrectomy and lensectomy. Knowledge of the intravitreal pharmacokinetics of the anti-VEGF drugs that were used in clinical practice is of vital importance.https://www.mdpi.com/1999-4923/11/8/365vascular endothelial growth factor/antagonists &inhibitorsranibizumabafliberceptbevacizumabAge-Related Macular Degenerationpharmacokineticsintravitreal |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura García-Quintanilla Andrea Luaces-Rodríguez María Gil-Martínez Cristina Mondelo-García Olalla Maroñas Víctor Mangas-Sanjuan Miguel González-Barcia Irene Zarra-Ferro Pablo Aguiar Francisco J. Otero-Espinar Anxo Fernández-Ferreiro |
spellingShingle |
Laura García-Quintanilla Andrea Luaces-Rodríguez María Gil-Martínez Cristina Mondelo-García Olalla Maroñas Víctor Mangas-Sanjuan Miguel González-Barcia Irene Zarra-Ferro Pablo Aguiar Francisco J. Otero-Espinar Anxo Fernández-Ferreiro Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration Pharmaceutics vascular endothelial growth factor/antagonists & inhibitors ranibizumab aflibercept bevacizumab Age-Related Macular Degeneration pharmacokinetics intravitreal |
author_facet |
Laura García-Quintanilla Andrea Luaces-Rodríguez María Gil-Martínez Cristina Mondelo-García Olalla Maroñas Víctor Mangas-Sanjuan Miguel González-Barcia Irene Zarra-Ferro Pablo Aguiar Francisco J. Otero-Espinar Anxo Fernández-Ferreiro |
author_sort |
Laura García-Quintanilla |
title |
Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration |
title_short |
Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration |
title_full |
Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration |
title_fullStr |
Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration |
title_full_unstemmed |
Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration |
title_sort |
pharmacokinetics of intravitreal anti-vegf drugs in age-related macular degeneration |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2019-07-01 |
description |
Intravitreal administration of anti-vascular endothelial growth factor (VEGF) antibodies has become the standard treatment for Age-Related Macular Degeneration; however, the knowledge of their pharmacokinetics is limited. A comprehensive review of the preclinical and clinical pharmacokinetic data that were obtained in different studies with intravitreal bevacizumab, ranibizumab, and aflibercept has been conducted. Moreover, the factors that can influence the vitreous pharmacokinetics of these drugs, as well as the methods that were used in the studies for analytical determination, have been exposed. These anti-VEGF drugs present different charge and molecular weights, which play an important role in vitreous distribution and elimination. The pharmacokinetic parameters that were collected differ depending on the species that were involved in the studies and on physiological and pathological conditions, such as vitrectomy and lensectomy. Knowledge of the intravitreal pharmacokinetics of the anti-VEGF drugs that were used in clinical practice is of vital importance. |
topic |
vascular endothelial growth factor/antagonists & inhibitors ranibizumab aflibercept bevacizumab Age-Related Macular Degeneration pharmacokinetics intravitreal |
url |
https://www.mdpi.com/1999-4923/11/8/365 |
work_keys_str_mv |
AT lauragarciaquintanilla pharmacokineticsofintravitrealantivegfdrugsinagerelatedmaculardegeneration AT andrealuacesrodriguez pharmacokineticsofintravitrealantivegfdrugsinagerelatedmaculardegeneration AT mariagilmartinez pharmacokineticsofintravitrealantivegfdrugsinagerelatedmaculardegeneration AT cristinamondelogarcia pharmacokineticsofintravitrealantivegfdrugsinagerelatedmaculardegeneration AT olallamaronas pharmacokineticsofintravitrealantivegfdrugsinagerelatedmaculardegeneration AT victormangassanjuan pharmacokineticsofintravitrealantivegfdrugsinagerelatedmaculardegeneration AT miguelgonzalezbarcia pharmacokineticsofintravitrealantivegfdrugsinagerelatedmaculardegeneration AT irenezarraferro pharmacokineticsofintravitrealantivegfdrugsinagerelatedmaculardegeneration AT pabloaguiar pharmacokineticsofintravitrealantivegfdrugsinagerelatedmaculardegeneration AT franciscojoteroespinar pharmacokineticsofintravitrealantivegfdrugsinagerelatedmaculardegeneration AT anxofernandezferreiro pharmacokineticsofintravitrealantivegfdrugsinagerelatedmaculardegeneration |
_version_ |
1724871128982224896 |