Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment.

B-cells not only produce immunoglobulins and present antigens to T-cells, but also additional key roles in the immune system. Current knowledge on the role of B-cells in infections caused by intracellular bacteria is fragmentary and contradictory. We therefore analysed the phenotypical and functiona...

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Bibliographic Details
Main Authors: Simone A Joosten, Krista E van Meijgaarden, Franca Del Nonno, Andrea Baiocchini, Linda Petrone, Valentina Vanini, Hermelijn H Smits, Fabrizio Palmieri, Delia Goletti, Tom H M Ottenhoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4909319?pdf=render