Persistence of CRISPR/Cas9 gene edited hematopoietic stem cells following transplantation: A systematic review and meta‐analysis of preclinical studies

Persistence of CRISPR/Cas9 gene edited hematopoietic stem cells following transplantation: A systematic review and meta‐analysis of preclinical studies

Abstract Gene editing blood‐derived cells is an attractive approach to cure selected monogenic diseases but remains experimental. A systematic search of preclinical controlled studies is needed to determine the persistence of edited cells following reinfusion. All studies identified in our systemati...

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Bibliographic Details
Main Authors: Harinad B. Maganti, Adrian J. M. Bailey, Aidan M. Kirkham, Risa Shorr, Nicolas Pineault, David S. Allan
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Stem Cells Translational Medicine
Subjects:
CRISPR/Cas9
gene editing
gene therapy
genetic disease
hematopoietic stem cells
monogenic disorders
Online Access:https://doi.org/10.1002/sctm.20-0520

Internet

https://doi.org/10.1002/sctm.20-0520

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