Genetic ablation of Gpnmb does not alter synuclein-related pathology

Genetic ablation of Gpnmb does not alter synuclein-related pathology

The gene GPNMB is known to play roles in phagocytosis and tissue repair, and is upregulated in microglia in many mouse models of neurodegenerative disease as well as in human patients. Nearby genomic variants are associated with both elevated Parkinson's disease (PD) risk and higher expression...

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Bibliographic Details
Main Authors: Robert Brendza, Han Lin, Kimberly Stark, Oded Foreman, Janet Tao, Andrew Pierce, Hai Ngu, Kimberle Shen, Amy E. Easton, Tushar Bhangale, Diana Chang, Baris Bingol, Brad A. Friedman
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Genetics
GPNMB
eQTL
Phagocytosis
Alpha synuclein
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121002436

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http://www.sciencedirect.com/science/article/pii/S0969996121002436

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