Deep evolutionary conservation of an intramolecular protein kinase activation mechanism.

Deep evolutionary conservation of an intramolecular protein kinase activation mechanism.

DYRK-family kinases employ an intramolecular mechanism to autophosphorylate a critical tyrosine residue in the activation loop. Once phosphorylated, DYRKs lose tyrosine kinase activity and function as serine/threonine kinases. DYRKs have been characterized in organisms from yeast to human; however,...

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Bibliographic Details
Main Authors: Jingfen Han, Diego Miranda-Saavedra, Nathan Luebbering, Aman Singh, Gary Sibbet, Michael A J Ferguson, Vaughn Cleghon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3250476?pdf=render

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http://europepmc.org/articles/PMC3250476?pdf=render

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