Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

<p>Abstract</p> <p>Background</p> <p>Neuroinflammation is associated with virtually all major neurodegenerative disorders, including Alzheimer’s disease (AD). Although it remains unclear whether neuroinflammation is the driving force behind these disorders, compelling e...

Full description

Bibliographic Details
Main Authors: Tweedie David, Ferguson Ryan A, Fishman Kelly, Frankola Kathryn A, Van Praag Henriette, Holloway Harold W, Luo Weiming, Li Yazhou, Caracciolo Luca, Russo Isabella, Barlati Sergio, Ray Balmiki, Lahiri Debomoy K, Bosetti Francesca, Greig Nigel H, Rosi Susanna
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Neurodegeneration
TNF-α
Neuroprotection
Alzheimer’s disease
Mild cognitive impairment
Amyoid-β peptide
Tau
Thalidomide
Lenalidomide
Online Access:http://www.jneuroinflammation.com/9/1/106

Internet

http://www.jneuroinflammation.com/9/1/106

Similar Items