Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer

Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer

Ovarian cancer (OC) has an overall modest number of mutations that facilitate a functional immune infiltrate able to recognize tumor mutated antigens, or neoantigens. Although patient-derived xenografts (PDXs) can partially model the tumor mutational load and mimic response to chemotherapy, no study...

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Bibliographic Details
Main Authors: Muzamil Yaqub Want, Anna Konstorum, Ruea-Yea Huang, Vaibhav Jain, Satoko Matsueda, Takemasa Tsuji, Amit Lugade, Kunle Odunsi, Richard Koya, Sebastiano Battaglia
Format: Article
Language:English
Published: Taylor & Francis Group 2019-06-01
Series:OncoImmunology
Subjects:
neoantigen
ovarian cancer
genomics
immunogenomics
tcr
pdx models
immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1586042

Internet

http://dx.doi.org/10.1080/2162402X.2019.1586042

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