Studies on the Two Thymine Residues in the Catalytic Core of 10-23 DNAzyme: The Impact on the Catalysis of Their 5-Substituted Functional Groups

Studies on the Two Thymine Residues in the Catalytic Core of 10-23 DNAzyme: The Impact on the Catalysis of Their 5-Substituted Functional Groups

In the 15-mer catalytic core of 10-23 DNAzyme, each residue contributes to the catalytic conformation differently. Here, the critically conserved T4 and the least conserved T8 were modified on their 5-position with hydroxyl, imidazolyl, and amino groups with a hydrogen-bonding ability. These externa...

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Bibliographic Details
Main Authors: Pengyu Li, Shanshan Du, Yang Li, Junlin He
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Molecules
Subjects:
10-23 DNAzyme
chemical modifications
thymine
functional group
catalytic core
observed catalytic constants
Online Access:http://www.mdpi.com/1420-3049/22/7/1011

Internet

http://www.mdpi.com/1420-3049/22/7/1011

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