Studies on the Two Thymine Residues in the Catalytic Core of 10-23 DNAzyme: The Impact on the Catalysis of Their 5-Substituted Functional Groups
In the 15-mer catalytic core of 10-23 DNAzyme, each residue contributes to the catalytic conformation differently. Here, the critically conserved T4 and the least conserved T8 were modified on their 5-position with hydroxyl, imidazolyl, and amino groups with a hydrogen-bonding ability. These externa...
Main Authors: | Pengyu Li, Shanshan Du, Yang Li, Junlin He |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2017-06-01
|
Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/22/7/1011 |
Similar Items
-
The Application of Ribozymes and DNAzymes in Muscle and Brain
by: Leonidas A. Phylactou, et al.
Published: (2010-08-01) -
Effect of Distance from Catalytic Synergy Group to Iron Porphyrin Center on Activity of G-Quadruplex/Hemin DNAzyme
by: Dehui Qiu, et al.
Published: (2020-07-01) -
Catalytic cleavage activities of 10–23 DNAzyme analogs functionalized with an amino group in its catalytic core
by: Qi Wang, et al.
Published: (2012-02-01) -
Catalytic Activities of Ribozymes and DNAzymes in Water and Mixed Aqueous Media
by: Shu-ichi Nakano, et al.
Published: (2017-11-01) -
Catalytic Activities of Multimeric G-Quadruplex DNAzymes
by: Raphael I. Adeoye, et al.
Published: (2019-07-01)