Orthologous promoters from related methylotrophic yeasts surpass expression of endogenous promoters of Pichia pastoris

Orthologous promoters from related methylotrophic yeasts surpass expression of endogenous promoters of Pichia pastoris

Abstract Methylotrophic yeasts such as Komagataella phaffii (syn. Pichia pastoris, Pp), Hansenula polymorpha (Hp), Candida boidinii (Cb) and Pichia methanolica (Pm) are widely used protein production platforms. Typically, strong, tightly regulated promoters of genes coding for their methanol utiliza...

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Bibliographic Details
Main Authors: Thomas Vogl, Jasmin Elgin Fischer, Patrick Hyden, Richard Wasmayer, Lukas Sturmberger, Anton Glieder
Format: Article
Language:English
Published: SpringerOpen 2020-02-01
Series:AMB Express
Subjects:
Pichia pastoris
Komagataella phaffii
Orthologous promoters
Methanol-free
Derepression
Online Access:http://link.springer.com/article/10.1186/s13568-020-00972-1

Internet

http://link.springer.com/article/10.1186/s13568-020-00972-1

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