Extensions of ℓ 1 regularization increase detection specificity for cell-type specific parameters in dynamic models

Extensions of ℓ 1 regularization increase detection specificity for cell-type specific parameters in dynamic models

Abstract Background Ordinary differential equation systems are frequently utilized to model biological systems and to infer knowledge about underlying properties. For instance, the development of drugs requires the knowledge to which extent malign cells differ from healthy ones to provide a specific...

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Bibliographic Details
Main Authors: Pascal Dolejsch, Helge Hass, Jens Timmer
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Bioinformatics
Subjects:
Systems biology
Dynamic models
Regularization
Feature selection
Accuracy
Sensitivity
Online Access:http://link.springer.com/article/10.1186/s12859-019-2976-1

Internet

http://link.springer.com/article/10.1186/s12859-019-2976-1

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