An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies.

An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies.

Characterizing the distribution of effects from genome-wide genotyping data is crucial for understanding important aspects of the genetic architecture of complex traits, such as number or proportion of non-null loci, average proportion of phenotypic variance explained per non-null effect, power for...

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Bibliographic Details
Main Authors: Wesley K Thompson, Yunpeng Wang, Andrew J Schork, Aree Witoelar, Verena Zuber, Shujing Xu, Thomas Werge, Dominic Holland, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Ole A Andreassen, Anders M Dale
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5456456?pdf=render

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http://europepmc.org/articles/PMC5456456?pdf=render

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