Landscape of Bone Marrow Metastasis in Human Neuroblastoma Unraveled by Transcriptomics and Deep Multiplex Imaging

Landscape of Bone Marrow Metastasis in Human Neuroblastoma Unraveled by Transcriptomics and Deep Multiplex Imaging

While the bone marrow attracts tumor cells in many solid cancers leading to poor outcome in affected patients, comprehensive analyses of bone marrow metastases have not been performed on a single-cell level. We here set out to capture tumor heterogeneity and unravel microenvironmental changes in neu...

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Bibliographic Details
Main Authors: Daria Lazic, Florian Kromp, Fikret Rifatbegovic, Peter Repiscak, Michael Kirr, Filip Mivalt, Florian Halbritter, Marie Bernkopf, Andrea Bileck, Marek Ussowicz, Inge M. Ambros, Peter F. Ambros, Christopher Gerner, Ruth Ladenstein, Christian Ostalecki, Sabine Taschner-Mandl
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
bone marrow
metastasis
neuroblastoma
tumor heterogeneity
tumor microenvironment
single-cell analysis
Online Access:https://www.mdpi.com/2072-6694/13/17/4311

Internet

https://www.mdpi.com/2072-6694/13/17/4311

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