Immune evasion by TGFβ-induced miR-183 repression of MICA/B expression in human lung tumor cells

Immune evasion by TGFβ-induced miR-183 repression of MICA/B expression in human lung tumor cells

Immune escape is a hallmark of cancer. In human lung cancer, we have identified a unique microRNA (miR)-based pathway employed by tumor cells to repress detection by immune cells via the NKG2D-MICA/B receptor-ligand system. MICA/B is readily induced by cell transformation and serves as a danger sign...

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Bibliographic Details
Main Authors: Thu Le Trinh, Wendy M. Kandell, Sarah S. Donatelli, Nhan Tu, Melba M. Tejera, Danielle L. Gilvary, Erika A. Eksioglu, Alexis Burnette, William A. Adams, Jinhong Liu, Jamie K. Teer, Julie Y. Djeu, Domenico Coppola, Sheng Wei
Format: Article
Language:English
Published: Taylor & Francis Group 2019-04-01
Series:OncoImmunology
Subjects:
immune evasion
nkg2d-mica/b
non-small cell lung cancer
nk cells
t cells
mirr-183
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1557372

Internet

http://dx.doi.org/10.1080/2162402X.2018.1557372

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