Synthetic Human TLR9-LRR11 Peptide Attenuates TLR9 Signaling by Binding to and thus Decreasing Internalization of CpG Oligodeoxynucleotides

Synthetic Human TLR9-LRR11 Peptide Attenuates TLR9 Signaling by Binding to and thus Decreasing Internalization of CpG Oligodeoxynucleotides

Toll-like receptor (TLR) 9 is an endosomal receptor recognizing bacterial DNA/CpG-containing oligodeoxynucleotides (CpG ODN). Blocking CpG ODN/TLR9 activity represents a strategy for therapeutic prevention of immune system overactivation. Herein, we report that a synthetic peptide (SP) representing...

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Bibliographic Details
Main Authors: Xichun Pan, Bin Li, Mei Kuang, Xin Liu, Yanyan Cen, Rongxin Qin, Guofu Ding, Jiang Zheng, Hong Zhou
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:International Journal of Molecular Sciences
Subjects:
CpG oligodeoxynucleotides
TLR9
Toll-like receptor 9
synthetic peptide
proinflammatory cytokine
nuclear factor
phosphorylation
internalization
Online Access:http://www.mdpi.com/1422-0067/17/2/242

Internet

http://www.mdpi.com/1422-0067/17/2/242

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