High resolution melting curve analysis, a rapid and affordable method for mutation analysis in childhood acute myeloid leukemia

High resolution melting curve analysis, a rapid and affordable method for mutation analysis in childhood acute myeloid leukemia

Background: Molecular genetic alterations with prognostic significance have been described in childhood acute myeloid leukemia (AML). The aim of this study was to establish cost-effective techniques to detect mutations of FMS-like tyrosine kinase 3 (FLT3), Nucleophosmin 1 (NPM1), and a partial tande...

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Bibliographic Details
Main Authors: Yin eLiu, Jingyan eTang, Peter eWakamatsu, Huiliang eXue, Jing eChen, Paul S Gaynon, Shuhong eShen, Weili eSun
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Pediatrics
Subjects:
Acute Myeloid Leukemia
childhood
FLT3
NPM1
MLL
High Resolution Melting curve analysis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fped.2014.00096/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fped.2014.00096/full

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