Microneutralization assay titer correlates analysis in two phase 3 trials of the CYD-TDV tetravalent dengue vaccine in Asia and Latin America.

Microneutralization assay titer correlates analysis in two phase 3 trials of the CYD-TDV tetravalent dengue vaccine in Asia and Latin America.

We previously showed that Month 13 50% plaque reduction neutralization test (PRNT50) neutralizing antibody (nAb) titers against dengue virus (DENV) correlated with vaccine efficacy (VE) of CYD-TDV against symptomatic, virologically-confirmed dengue (VCD) in the CYD14 and CYD15 Phase 3 trials. While...

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Bibliographic Details
Main Authors: Lindsay N Carpp, Youyi Fong, Matthew Bonaparte, Zoe Moodie, Michal Juraska, Ying Huang, Brenda Price, Yingying Zhuang, Jason Shao, Lingyi Zheng, Laurent Chambonneau, Robert Small, Saranya Sridhar, Carlos A DiazGranados, Peter B Gilbert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0234236

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https://doi.org/10.1371/journal.pone.0234236

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