Hydrazinocurcumin and 5-fluorouracil enhance apoptosis and restrain tumorigenicity of HepG2 cells via disrupting the PTEN-mediated PI3K/Akt signaling pathway

Hydrazinocurcumin and 5-fluorouracil enhance apoptosis and restrain tumorigenicity of HepG2 cells via disrupting the PTEN-mediated PI3K/Akt signaling pathway

Hydrazinocurcumin (HZC), a curcumin analogue, serves as a tumor suppressor in breast cancer and lung cancer. In this study, we investigate the role and mechanism of HZC in regulating HepG2 cell apoptosis and tumorigenicity, and its synergistic effects with 5-fluorouracil (5-Fu). HepG2 cells were tre...

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Bibliographic Details
Main Authors: Ye Zhou, Meng Zhang, Zhilei Zhang, Yuming Jia, Chong Zhang, Li Peng
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hydrazinocurcumin
Hepatocellular carcinoma
5-fluorouracil
Phosphatase and tensin homolog
PI3K/Akt signaling pathway
Cell apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222030041X

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http://www.sciencedirect.com/science/article/pii/S075333222030041X

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