ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective

Human aging is currently defined as a physiological decline of biological functions in the body with a continual adaptation to internal and external damaging. The endocrine system plays a major role in orchestrating cellular interactions, metabolism, growth, and aging. Several in vivo studies from w...

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Bibliographic Details
Main Authors: Giovanni Vitale, Giuseppe Pellegrino, Maria Vollery, Leo J. Hofland
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Endocrinology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00027/full