Disease Modifying Therapies for Alzheimer's Disease Targeting Aβ Oligomers: Implications for Therapeutic Mechanisms

Several lines of evidence indicate that amyloid β (Aβ), particularly Aβ oligomers (AβOs), plays a causative role in Alzheimer's disease. However, the mechanisms underlying the action of an anti-AβO antibody to clarify the toxic action of AβOs remain elusive. Here, we showed that the anti-AβO a...

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Bibliographic Details
Main Authors: Etsuro Matsubara, Ayumi Takamura, Yasuhide Okamoto, Hideto Oono, Takashi Nakata, Yasuhito Wakasaya, Takeshi Kawarabayashi, Mikio Shoji
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/984041