Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4β-Triazolopodophyllotoxin Derivatives

Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4β-Triazolopodophyllotoxin Derivatives

A series of novel perbutyrylated glycosides of 4β-triazolopodophyllotoxin derivatives were synthesized by utilizing the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. Evaluation of cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) usi...

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Bibliographic Details
Main Authors: Cheng-Ting Zi, Zhen-Hua Liu, Gen-Tao Li, Yan Li, Jun Zhou, Zhong-Tao Ding, Jiang-Miao Hu, Zi-Hua Jiang
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:Molecules
Subjects:
podophyllotoxin
glycosylated
4β-triazole
CuAAC reaction
antitumor
synthesis
Online Access:http://www.mdpi.com/1420-3049/20/2/3255

Internet

http://www.mdpi.com/1420-3049/20/2/3255

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