Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes

Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes

The aetiology of rheumatoid arthritis (RA) is unknown, but citrullination of proteins is thought to be an initiating event. In addition, it is increasingly evident that the lung can be a potential site for the generation of autoimmune triggers before the development of joint disease. Here, we identi...

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Bibliographic Details
Main Authors: Valerie R. Wiersma, Alex Clarke, Simon D. Pouwels, Elizabeth Perry, Trefa M. Abdullah, Clive Kelly, Anthony De Soyza, David Hutchinson, Paul Eggleton, Edwin Bremer
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
rheumatoid arthritis
bronchiectasis
neutrophil
granulocytes
citrullination
inflammatory cytokines
peptidyl-arginine deiminase
galectin
Online Access:https://www.mdpi.com/1422-0067/20/16/4046

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https://www.mdpi.com/1422-0067/20/16/4046

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