S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis

S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis

Background: One-third of all deaths in hospitals are caused by sepsis. Despite its demonstrated prevalence and high case fatality rate, antibiotics remain the only target-oriented treatment option currently available. Starting from results showing that low-dose anthracyclines protect against sepsis...

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Bibliographic Details
Main Authors: Cynthia Weigel, Sören S. Hüttner, Kristin Ludwig, Nadine Krieg, Susann Hofmann, Nathalie H. Schröder, Linda Robbe, Stefan Kluge, Axel Nierhaus, Martin S. Winkler, Ignacio Rubio, Julia von Maltzahn, Sarah Spiegel, Markus H. Gräler
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:EBioMedicine
Subjects:
Sphingosine 1-phosphate
Epirubicin
Anthracycline
Epithelial barrier
Lung
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420302735

Internet

http://www.sciencedirect.com/science/article/pii/S2352396420302735

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