Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor–Deficient Zebrafish

Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor–Deficient Zebrafish

The glucagon receptor (GCGR) is activated by glucagon and is essential for glucose, amino acid, and lipid metabolism of animals. GCGR blockade has been demonstrated to induce hypoglycemia, hyperaminoacidemia, hyperglucagonemia, decreased adiposity, hepatosteatosis, and pancreatic α cells hyperplasia...

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Bibliographic Details
Main Authors: Xuanxuan Bai, Jianxin Jia, Qi Kang, Yadong Fu, You Zhou, Yingbin Zhong, Chao Zhang, Mingyu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
glucagon receptor
glucagon
metabolomics
lipidomics
zebrafish
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.605979/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.605979/full

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