Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced spine turnover has enhanced learning.

Bibliographic Details
Main Authors:	Adam C. Frank, Shan Huang, Miou Zhou, Amos Gdalyahu, George Kastellakis, Tawnie K. Silva, Elaine Lu, Ximiao Wen, Panayiota Poirazi, Joshua T. Trachtenberg, Alcino J. Silva
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02751-2

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spelling	doaj-9812b8e6055c436ab27e845c4f6d0c382021-05-11T10:29:33ZengNature Publishing GroupNature Communications2041-17232018-01-019111110.1038/s41467-017-02751-2Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memoryAdam C. Frank0Shan Huang1Miou Zhou2Amos Gdalyahu3George Kastellakis4Tawnie K. Silva5Elaine Lu6Ximiao Wen7Panayiota Poirazi8Joshua T. Trachtenberg9Alcino J. Silva10Department of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of CaliforniaDepartment of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of CaliforniaDepartment of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of CaliforniaDepartment of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of CaliforniaInstitute for Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), GRDepartment of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of CaliforniaDepartment of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of CaliforniaDepartment of Mechanical and Aerospace Engineering, University of CaliforniaInstitute for Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), GRDepartment of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of CaliforniaDepartment of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of CaliforniaStructural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced spine turnover has enhanced learning.https://doi.org/10.1038/s41467-017-02751-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Adam C. Frank Shan Huang Miou Zhou Amos Gdalyahu George Kastellakis Tawnie K. Silva Elaine Lu Ximiao Wen Panayiota Poirazi Joshua T. Trachtenberg Alcino J. Silva
spellingShingle	Adam C. Frank Shan Huang Miou Zhou Amos Gdalyahu George Kastellakis Tawnie K. Silva Elaine Lu Ximiao Wen Panayiota Poirazi Joshua T. Trachtenberg Alcino J. Silva Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory Nature Communications
author_facet	Adam C. Frank Shan Huang Miou Zhou Amos Gdalyahu George Kastellakis Tawnie K. Silva Elaine Lu Ximiao Wen Panayiota Poirazi Joshua T. Trachtenberg Alcino J. Silva
author_sort	Adam C. Frank
title	Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
title_short	Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
title_full	Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
title_fullStr	Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
title_full_unstemmed	Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
title_sort	hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced spine turnover has enhanced learning.
url	https://doi.org/10.1038/s41467-017-02751-2
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Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

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