Elimination of hepatitis C virus from hepatocytes by a selective activation of therapeutic molecules.

Elimination of hepatitis C virus from hepatocytes by a selective activation of therapeutic molecules.

To eliminate hepatitis C virus (HCV) from infected hepatocytes, we generated two therapeutic molecules specifically activated in cells infected with HCV. A dominant active mutant of interferon (IFN) regulatory factor 7 (IRF7) and a negative regulator of HCV replication, VAP-C (Vesicle-associated mem...

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Bibliographic Details
Main Authors: Xiaoyu Wen, Takayuki Abe, Hiroshi Kukihara, Shuhei Taguwa, Yoshio Mori, Hideki Tani, Nobuyuki Kato, Tetsuro Suzuki, Masashi Tatsumi, Kohji Moriishi, Yoshiharu Matsuura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3017098?pdf=render

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http://europepmc.org/articles/PMC3017098?pdf=render

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