Protective effects of Panax notoginseng saponins on PME-Induced nephrotoxicity in mice

Polymyxin E (PME) plays an important role in fighting against Gram-negative bacterial infections; however, it causes nephrotoxicity, which limits its clinical use. The aim of this study was to investigate the protective effects of a plant extract Panax notoginseng saponins (PNS) on PME-induced nephr...

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Bibliographic Details
Main Authors: Yong Zhang, Xiaoqing Chi, Zizengchen Wang, Shicheng Bi, Yuemin Wang, Fushan Shi, Songhua Hu, Huanan Wang
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Biomedicine & Pharmacotherapy
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Online Access:http://www.sciencedirect.com/science/article/pii/S075333221930589X