tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated tp53 deleted zebrafish that spontaneously develop malignant peripheral nerve-sheath tumors, angiosarcomas, germ cell...

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Bibliographic Details
Main Authors: Myron S Ignatius, Madeline N Hayes, Finola E Moore, Qin Tang, Sara P Garcia, Patrick R Blackburn, Kunal Baxi, Long Wang, Alexander Jin, Ashwin Ramakrishnan, Sophia Reeder, Yidong Chen, Gunnlaugur Petur Nielsen, Eleanor Y Chen, Robert P Hasserjian, Franck Tirode, Stephen C Ekker, David M Langenau
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
angiosarcoma
germ cell tumor
MPNST
leukemia
rhabdomyosarcoma
metastasis
Online Access:https://elifesciences.org/articles/37202

Internet

https://elifesciences.org/articles/37202

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