USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination

USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination

The tumor suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancers (CRCs), resulting in constitutive Wnt activation. To understand the Wnt-activating mechanism of the APC mutation, we applied CRISPR/Cas9 technology to engineer various APC-truncated isogenic lines. We fi...

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Bibliographic Details
Main Authors: Laura Novellasdemunt, Valentina Foglizzo, Laura Cuadrado, Pedro Antas, Anna Kucharska, Vesela Encheva, Ambrosius P. Snijders, Vivian S.W. Li
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
Wnt signaling
APC
β-catenin
ubiquitination
USP7
colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313773

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http://www.sciencedirect.com/science/article/pii/S2211124717313773

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