Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood–Brain Barrier in vivo and in vitro

Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood–Brain Barrier in vivo and in vitro

Ischemia/reperfusion injury is a major cause of acute kidney injury (AKI). AKI is characterized by a sudden decrease in kidney function, systemic inflammation, oxidative stress, and dysregulation of the sodium, potassium, and water channels. While AKI leads to uremic encephalopathy, epidemiological...

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Bibliographic Details
Main Authors: Malgorzata Burek, Sandra Burmester, Ellaine Salvador, Kerstin Möller-Ehrlich, Reinhard Schneider, Norbert Roewer, Michiaki Nagai, Carola Y. Förster
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
kidney ischemia/reperfusion injury
brain pathology
blood–brain barrier
drug transporter
tight junctions
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.569881/full

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https://www.frontiersin.org/articles/10.3389/fphys.2020.569881/full

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