Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β

Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β

Brain-derived neurotrophic factor (BDNF) plays important functions in cell survival and differentiation, neuronal outgrowth and plasticity. In Alzheimer’s disease (AD), BDNF signaling is known to be impaired, partially because amyloid β (Aβ) induces truncation of BDNF main receptor, TrkB-full length...

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Bibliographic Details
Main Authors: Sara R. Tanqueiro, Rita M. Ramalho, Tiago M. Rodrigues, Luísa V. Lopes, Ana M. Sebastião, Maria J. Diógenes
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
brain-derived neurotrophic factor
TrkB receptor
extrasynaptic N-methyl-d-aspartate receptors
memantine
long-term potentiation
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00237/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00237/full

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