Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy

Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy

The dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin has been found to reduce progressive albuminuria, but the exact mechanism of inhibition is unclear. Podocyte epithelial-to-mesenchymal transition (EMT) has emerged as a potential pathway leading to proteinuria in diabetic nephropathy (DN). Str...

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Bibliographic Details
Main Authors: Yun-peng Chang, Bei Sun, Zhe Han, Fei Han, Shao-lan Hu, Xiao-yu Li, Mei Xue, Yang Yang, Li Chen, Chun-jun Li, Li-ming Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
diabetic nephropathy
podocyte epithelial-to-mesenchymal transition
saxagliptin
NOX2
SDF-1α
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00780/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00780/full

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