Isocaloric Substitution of Dietary Carbohydrate Intake with Fat Intake and MRI-Determined Total Volumes of Visceral, Subcutaneous and Hepatic Fat Content in Middle-Aged Adults
The present study investigated the association of carbohydrate intake and isocaloric substitution with different types of fat with visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and hepatic fat content as determined by magnetic resonance imaging (MRI). Data from 283 participants (m...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-05-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/11/5/1151 |
id |
doaj-9828c68fbe874feb94bb43d7d13058d4 |
---|---|
record_format |
Article |
spelling |
doaj-9828c68fbe874feb94bb43d7d13058d42020-11-25T00:47:02ZengMDPI AGNutrients2072-66432019-05-01115115110.3390/nu11051151nu11051151Isocaloric Substitution of Dietary Carbohydrate Intake with Fat Intake and MRI-Determined Total Volumes of Visceral, Subcutaneous and Hepatic Fat Content in Middle-Aged AdultsChrista Meisinger0Susanne Rospleszcz1Elke Wintermeyer2Roberto Lorbeer3Barbara Thorand4Fabian Bamberg5Annette Peters6Christopher L. Schlett7Jakob Linseisen8Chair of Epidemiology, Ludwig-Maximilians Universität München at UNIKA-T Augsburg, 86156 Augsburg, GermanyInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, GermanySiegfried Weller Institute for Trauma Research, BG Trauma Center Tuebingen, Eberhard-Karls University Tuebingen, 72074 Tuebingen, GermanyDepartment of Radiology, Ludwig Maximilians University Hospital, 81377 Munich, GermanyInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, GermanyDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, GermanyInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, GermanyDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, GermanyChair of Epidemiology, Ludwig-Maximilians Universität München at UNIKA-T Augsburg, 86156 Augsburg, GermanyThe present study investigated the association of carbohydrate intake and isocaloric substitution with different types of fat with visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and hepatic fat content as determined by magnetic resonance imaging (MRI). Data from 283 participants (mean age 56.1 ± 9.0 years) from the MRI sub study of the KORA FF4 study were included. VAT, SAT and total body fat were quantified by a volume-interpolated VIBE-T1w-Dixon MR sequence. Hepatic fat content was determined as the proton density fat-fraction (PDFF) derived from multiecho-T1w MR sequence. Dietary intake was estimated using information provided by two different instruments, that is, repeated 24-h food lists and a food frequency questionnaire. Replacing total carbohydrates with an isoenergetic amount of total fat was significantly positively associated with VAT and hepatic fat, while there was no significant association with SAT. The multivariable adjusted β-coefficient for replacing 5% of total energy (5E%) carbohydrates with total fat was 0.42 L (95% CI: 0.04, 0.79) for VAT. A substitution in total fat intake by 5E% was associated with a significant increase in liver fat content by 23% (<i>p</i>-value 0.004). If reproduced in prospective studies, such findings would strongly argue for limiting dietary fat intake.https://www.mdpi.com/2072-6643/11/5/1151hepatic fat contentvisceral adipose tissuebody fat compartmentsfat intakedietMRI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christa Meisinger Susanne Rospleszcz Elke Wintermeyer Roberto Lorbeer Barbara Thorand Fabian Bamberg Annette Peters Christopher L. Schlett Jakob Linseisen |
spellingShingle |
Christa Meisinger Susanne Rospleszcz Elke Wintermeyer Roberto Lorbeer Barbara Thorand Fabian Bamberg Annette Peters Christopher L. Schlett Jakob Linseisen Isocaloric Substitution of Dietary Carbohydrate Intake with Fat Intake and MRI-Determined Total Volumes of Visceral, Subcutaneous and Hepatic Fat Content in Middle-Aged Adults Nutrients hepatic fat content visceral adipose tissue body fat compartments fat intake diet MRI |
author_facet |
Christa Meisinger Susanne Rospleszcz Elke Wintermeyer Roberto Lorbeer Barbara Thorand Fabian Bamberg Annette Peters Christopher L. Schlett Jakob Linseisen |
author_sort |
Christa Meisinger |
title |
Isocaloric Substitution of Dietary Carbohydrate Intake with Fat Intake and MRI-Determined Total Volumes of Visceral, Subcutaneous and Hepatic Fat Content in Middle-Aged Adults |
title_short |
Isocaloric Substitution of Dietary Carbohydrate Intake with Fat Intake and MRI-Determined Total Volumes of Visceral, Subcutaneous and Hepatic Fat Content in Middle-Aged Adults |
title_full |
Isocaloric Substitution of Dietary Carbohydrate Intake with Fat Intake and MRI-Determined Total Volumes of Visceral, Subcutaneous and Hepatic Fat Content in Middle-Aged Adults |
title_fullStr |
Isocaloric Substitution of Dietary Carbohydrate Intake with Fat Intake and MRI-Determined Total Volumes of Visceral, Subcutaneous and Hepatic Fat Content in Middle-Aged Adults |
title_full_unstemmed |
Isocaloric Substitution of Dietary Carbohydrate Intake with Fat Intake and MRI-Determined Total Volumes of Visceral, Subcutaneous and Hepatic Fat Content in Middle-Aged Adults |
title_sort |
isocaloric substitution of dietary carbohydrate intake with fat intake and mri-determined total volumes of visceral, subcutaneous and hepatic fat content in middle-aged adults |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-05-01 |
description |
The present study investigated the association of carbohydrate intake and isocaloric substitution with different types of fat with visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and hepatic fat content as determined by magnetic resonance imaging (MRI). Data from 283 participants (mean age 56.1 ± 9.0 years) from the MRI sub study of the KORA FF4 study were included. VAT, SAT and total body fat were quantified by a volume-interpolated VIBE-T1w-Dixon MR sequence. Hepatic fat content was determined as the proton density fat-fraction (PDFF) derived from multiecho-T1w MR sequence. Dietary intake was estimated using information provided by two different instruments, that is, repeated 24-h food lists and a food frequency questionnaire. Replacing total carbohydrates with an isoenergetic amount of total fat was significantly positively associated with VAT and hepatic fat, while there was no significant association with SAT. The multivariable adjusted β-coefficient for replacing 5% of total energy (5E%) carbohydrates with total fat was 0.42 L (95% CI: 0.04, 0.79) for VAT. A substitution in total fat intake by 5E% was associated with a significant increase in liver fat content by 23% (<i>p</i>-value 0.004). If reproduced in prospective studies, such findings would strongly argue for limiting dietary fat intake. |
topic |
hepatic fat content visceral adipose tissue body fat compartments fat intake diet MRI |
url |
https://www.mdpi.com/2072-6643/11/5/1151 |
work_keys_str_mv |
AT christameisinger isocaloricsubstitutionofdietarycarbohydrateintakewithfatintakeandmrideterminedtotalvolumesofvisceralsubcutaneousandhepaticfatcontentinmiddleagedadults AT susannerospleszcz isocaloricsubstitutionofdietarycarbohydrateintakewithfatintakeandmrideterminedtotalvolumesofvisceralsubcutaneousandhepaticfatcontentinmiddleagedadults AT elkewintermeyer isocaloricsubstitutionofdietarycarbohydrateintakewithfatintakeandmrideterminedtotalvolumesofvisceralsubcutaneousandhepaticfatcontentinmiddleagedadults AT robertolorbeer isocaloricsubstitutionofdietarycarbohydrateintakewithfatintakeandmrideterminedtotalvolumesofvisceralsubcutaneousandhepaticfatcontentinmiddleagedadults AT barbarathorand isocaloricsubstitutionofdietarycarbohydrateintakewithfatintakeandmrideterminedtotalvolumesofvisceralsubcutaneousandhepaticfatcontentinmiddleagedadults AT fabianbamberg isocaloricsubstitutionofdietarycarbohydrateintakewithfatintakeandmrideterminedtotalvolumesofvisceralsubcutaneousandhepaticfatcontentinmiddleagedadults AT annettepeters isocaloricsubstitutionofdietarycarbohydrateintakewithfatintakeandmrideterminedtotalvolumesofvisceralsubcutaneousandhepaticfatcontentinmiddleagedadults AT christopherlschlett isocaloricsubstitutionofdietarycarbohydrateintakewithfatintakeandmrideterminedtotalvolumesofvisceralsubcutaneousandhepaticfatcontentinmiddleagedadults AT jakoblinseisen isocaloricsubstitutionofdietarycarbohydrateintakewithfatintakeandmrideterminedtotalvolumesofvisceralsubcutaneousandhepaticfatcontentinmiddleagedadults |
_version_ |
1725262292337033216 |